![]() Centers for Disease Control and Prevention and the Russian State Centre for Research on Virology and Biotechnology each have smallpox samples for research purposes. Though smallpox was eradicated more than 40 years ago, there are still two known stockpiles of the virus. The company plans to introduce the new cell line in the next 18 months, he said. We need to think about how we are better prepared," the CEO said.īavarian Nordic's current production capacity is constrained by the fact that the weakened virus used in the vaccine is produced from chicken cells that come from special hen eggs.īavarian Nordic has developed a permanent avian cell line that will simplify production and make it easier to bring in other manufacturers in an emergency, Chaplin said. While mpox spreads mostly through close physical contact, smallpox infects people primarily through respiratory droplets, which means the virus has greater potential to spread widely.Īnd Bavarian Nordic's annual production capacity for Jynneos wouldn't be sufficient to deal with a wide-spread outbreak of smallpox, Chaplin said. "If that's the way it manifests itself again, I think we can manage." "It was contained in that risk population, it didn't spread," the CEO said of last year's outbreak. ![]() The company's current annual production capacity is between 15 and 20 million doses, Chaplin said. Mpox since last year has spread primarily through sexual contact among gay and bisexual men.īut the rate of new cases of the virus has declined dramatically as vaccine distribution ramped up and communities at risk had better information about what precautions to take.īavarian Nordic estimates that the potential demand for the mpox vaccine could reach tens of millions of doses. "The phone started ringing and we realized we were in a situation that we hadn't seen before," Chaplin said. that came from imported animals.īut when other countries in Europe started reporting cases of the virus last year, it became clear something unusual was happening, Chaplin said. In 2003, there was a small outbreak in the U.S. Sporadic cases of mpox had occurred in countries outside Africa by travelers in the past. government, thinking that this was, as usual, an isolated case," Chaplin said. And the skin lesions associated with the disease can cause excruciating pain.īavarian Nordic only had several thousand finished doses of Jynneos on hand when the United Kingdom reported the first known case of the epidemic to the WHO last May. Unlike smallpox, mpox is rarely lethal, but the virus can be deadly for people with severely compromised immune systems. Once limited mostly to Africa, mpox spread suddenly and rapidly around the world last summer, taking public health authorities and Bavarian Nordic by surprise. That contract was signed during the mpox outbreak. has a long-standing stockpile of more than 100 million doses of an older smallpox vaccine, called ACAM2000.īavarian Nordic will finish delivering an order of 5 million Jynneos doses for the U.S government in the first half of this year. "The discussions have definitely intensified and increased," he said. And now it's a mixture of mpox, but also more strategic stockpiling, including the smallpox indication," Chaplin said of discussions about future orders. In the wake of the mpox epidemic, the European Union's Health Emergency Preparedness and Response Authority and at least two European national governments have shown interest in stockpiling the Jynneos vaccine for use against smallpox, Chaplin said. It had a mortality rate of up to 30% depending on the strain, according to the WHO. Smallpox was one of the most deadly diseases known to humankind. ![]() "There are concerns either through reengineering or accidental outbreaks from containment, or other terrorist activities that it could be reintroduced," Chaplin said of smallpox. Though the risk of the virus returning is low, some governments don't want to take any chances. Smallpox was eradicated from the world in 1980 after a successful global vaccination campaign. The company's current production capacity is tens of millions of doses. Personal Loans for 670 Credit Score or Lower Personal Loans for 580 Credit Score or Lower Best Debt Consolidation Loans for Bad Credit
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